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Reininghaus B, Riedrich K, Dalkner N, Bengesser SA, Birner A, Platzer M, Hamm C, Gostner JM et al (2018) Changes in the tryptophan-kynurenine axis in association to therapeutic response in clinically depressed patients undergoing psychiatric rehabilitation

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The animals that survived for longer than 12 days were euthanized

Studies show the compound crosses the blood-brain barrier efficiently despite its peptide structure, achieving central nervous system concentrations sufficient for biological activity following systemic administration